Originally the home of Ardrey's Drug Store, this space was famously the location where proprietor W. B. Ardrey Sr. turned down a once-in-a-lifetime opportunity to get in on the ground floor of what became a worldwide brand. When presented with the chance to invest in a new syrup product by a salesman, he declined, believing it was not a good investment. The product turned out to be Coca-Cola.

Even so, Ardrey ran a successful business here for many years and may have been the only merchant in the area to regularly stock Indian pottery.

John Barron Mills (J.B.) owned and operated Mills Mercantile here. The store was a victim of the Main Street fires in multiple locations. He eventually moved the business off Main Street and near the railroad tracks. This building later became Eagle's Five & Dime Store.